1. One drug could treat Alzheimer’s, MS, Crohn’s and more

    One drug could treat Alzheimer’s, MS, Crohn’s and more

    Could one drug effectively treat incurable inflammatory diseases such as Crohn’s disease, ulcerative colitis, rheumatoid arthritis and multiple sclerosis as well as neurodegenerative maladies such as Alzheimer’s disease?

    Yes, says Prof. David Naor, speaking with ISRAEL21c at the Lautenberg Center for General and Tumor Immunology in Hebrew University-Hadassah Medical School, Jerusalem.

    All these diseases, he explains, are associated with pathological amyloid proteins that could be neutralized by the 5-mer peptide Naor has spent the last 10 years researching and developing with the support of the university’s Yissum technology-transfer company, the Israeli government and Spherium Biomed of Spain ...

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    1. I believe that within two years we would know for certain if our academic product can translate into a therapeutic drug to combat inflammatory and neurodegenerative diseases.
    2. Once the rheumatoid arthritis experiment was repeated successfully several times, we looked at a different chronic inflammatory disease – multiple sclerosis, where the inflammation is not in the joints but in the brain.
    3. That means that we may be able to produce pills for oral delivery rather than to provide the drug by injection.
    4. We can restore the memory of the animal. This doesn't mean we're going to cure Alzheimer's but it does mean we have to do everything possible to see if our peptide could be successful where so many other potential anti-Alzheimer drugs have failed.
    5. We can inject 5-mer peptide even after the disease has started, and it will work.
    6. Because the peptide was derived from human material, it makes sense that it is going to work in humans at least as well as in mice.
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